The current COVID-19 pandemic has impacted the world, specifically the response to the disease by industries such as construction. COVID-19 has changed the way industries approach protecting workers’ safety and PtD holds the promise to reduce workers’ exposure to health hazards. This second virtual, interactive PtD workshop, on May 26 and 27, 2021, will focus on what we have learned in the past year that can be translated to the future improvement of PtD moving into the post-COVID era. Lessons learned from online collaboration, regulatory guidance, modularization, artificial intelligence, work site ventilation, future building design and prevention through design processes will be explored providing a baseline for improvement. This 2021 workshop will create an excellent opportunity for architects, engineers, contractors, construction companies, project owners, insurers, and academia to exchange and leverage their experiences and expertise on PtD practices by meeting professionals worldwide.